View a few of our most notable publications from 2017:

 

Skin pigmentation genetics for the clinic
Ainger, Stephen A., Jagirdar, Kasturee, Lee, Katie J., Soyer, H. Peter and Sturm, Richard A. (2017) Skin pigmentation genetics for the clinic. Dermatology,. doi:10.1159/000468538

Generational shift in melanoma incidence and mortality in Queensland, Australia, 1995-2014.
Aitken JF, Youlden DR, Baade PD, Soyer HP, Green AC, Smithers BM. (2017) Generational shift in melanoma incidence and mortality in Queensland, Australia, 1995-2014. Int J Cancer. 2017 Nov 6. doi: 10.1002/ijc.31141. [Epub ahead of print]

Increased FcƴRIIb-dominance contributes to the emergence of resistance to therapeutic antibodies in chronic lymphocytic leukaemia patients
Burgess ML, Mapp S, Mazzieri R, Ellis J, Cheung C, Chambers L, Mattarollo S, Mollee P, Gill D, Saunders NA.  Increased FcƴRIIb-dominance contributes to the emergence of resistance to therapeutic antibodies in chronic lymphocytic leukaemia patients. Oncogene, 36:2366-2376, 2017.

Sirolimus increases T-cell abundance in the sun exposed skin of kidney transplant recipients
Burke, Michael Thomas, Sambira Nahum, Lauren C., Isbel, Nicole M., Carroll, Robert P., Soyer, Hans Peter, Francis, Ross, Bridge, Jennifer Anne, Hawley, Carmel, Oliver, Kimberly, Staatz, Christine E. and Wells, James William (2017) Sirolimus increases T-cell abundance in the sun exposed skin of kidney transplant recipients. Transplantation Direct,3 7: . doi:10.1097/TXD.0000000000000694

CD8(+) lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury
Chakraborty R, Chandra J, Cui S, Tolley L, Cooper MA, Kendall M, Frazer IH. (2017) CD8(+) lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury. Exp Dermatol 2017.

Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function
Chandra J, Kuo PT, Hahn AM, Belz GT, Frazer IH (2017) . Batf3 selectively determines acquisition of CD8(+) dendritic cell phenotype and function. Immunol Cell Biol 2017;95:215-223.

Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells.
Chhabra Y, Yong HXL, Fane ME, Soogrim A, Lim W, Mahiuddin DN, Kim RSQ, Ashcroft M, Beatson SA, Ainger SA, Smit DJ, Jagirdar K, Walker GJ, Sturm RA, Smith AG. (2018) Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma responses in melanocytic cells. Pigment Cell & Melanoma Research, In press (2017). Epub 2017 July 29

The duality of macrophage function in chronic lymphocytic leukaemia
Chen YCE, Mapp S, Blumenthal A,  Burgess ML, Mazzieri R, Mattarollo SR, Mollee P, Gill D, Saunders NA The duality of macrophage function in Chronic Lymphocytic Leukaemia. Invited Review  BBA Rev. Cancer. 1868(1):176-182, 2017.

A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF
Choi J, Xu M, Makowski MM, Zhang T, Law MH, Kovacs MA, Granzhan A, Kim WJ, Parikh H, Gartside M, Trent JM, Teulade-Fichou MP, Iles MM, Newton-Bishop JA, Bishop DT, MacGregor S, Hayward NK, Vermeulen M, Brown KM, (2017), A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF. Nat Genet. 49(9):1326-1335.

NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics
Cirenajwis H, Lauss M, Ekedahl H, Törngren T, Kvist A, Saal LH, Olsson H, Staaf J, Carneiro A, Ingvar C, Harbst K, HAYWARD NK, Jönsson G. NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics. Mol Oncol. 2017 Apr;11(4):438-451.

New insights into naevoid melanomas: a clinicopathological reassessment
Cook MG,  Massi M, Blokx WA, Van den Oord J, Koljenović S, De Giorgi V, Kissin E, Grant M, Mandal A, Gremel G, Gaudy C, Viros A, Dhomen N, Khosrotehrani K, Marais R, Mihm MC*, Green AC*. New insights into naevoid melanomas: a clinico-pathological reassessment. Histopathology. 2017 Dec;71(6):943-950. doi: 10.1111/his.13317. Epub 2017 Oct 2  [*joint last authors]

Estimated Healthcare Costs of Melanoma in Australia Over 3 Years Post-Diagnosis
Elliott T, Olsen C, Whiteman DC, Gordon LG. Estimated healthcare costs of melanoma in Australia over 3 years post diagnosis. Applied Health Economics and Health Policy. 2017;15(6):805-816. doi: 10.1007/s40258-017-0341-y. Erratum 2017 Sep 12. doi: 10.1007/s40258-017-0347-5.

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF
Fane, M., Chhabra, Y., Hollingsworth, D., Simmons, J.L., Spoerri, L., Oh, T.G., Chin, T., Harris, L., Harvey, T., Muscat, G.E.O., Sturm, R.A., Haass, N., Boyle, G.M., Piper, M. and Smith, A.G. (2017) NFIB mediates BRN2 driven melanoma cell migration and invasion via regulation of EZH2 and MITF. EBioMedicine. 16, 63-75.

Cost-Effectiveness Analysis of a Skin Awareness Intervention for Early Detection of Skin Cancer Targeting Men Older Than 50 Years
Gordon LG, Brynes J, Baade PD, Neale RE, Whiteman DC, Youl PH, Aitken JF, Janda M. (2017) Cost-effectiveness analysis of a skin awareness intervention for early detection of skin cancer targeting men over 50 years. Value Health. 2017 Apr;20(4):593-601. doi: 10.1016/j.jval.2016.12.017

Cutaneous squamous cell carcinoma: an epidemiological review
Green AC, Olsen CM. Cutaneous squamous cell carcinoma: an epidemiological Review. Br J Dermatol. 2017 Aug;177(2):373-381. doi: 10.1111/bjd.15324.

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O’Donnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, Hinze D, Rogava M, van der Sluis TC, Ruotsalainen JJ, Gaffal E, Landsberg J, Ludwig KU, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Scolyer RA, Long GV, Janzen V, Teng MWL, Kastenmüller W, Mazzone M, Smyth MJ, Tüting T, Hölzel M. (2017) Reactive neutrophil responses dependent on the receptor tyrosine kinase c-MET limit cancer immunotherapy. Immunity 47:789-802 2017 [1].

Multiplicity of skin cancers in Queensland and their cost burden to government and patients
Gordon LG, Elliott T, Olsen C, Pandeya N, Whiteman DC. (2017) Multiplicity of skin cancers in Queensland and their cost burden to government and patients. ANZJPH. 2017 Nov 22. doi: 10.1111/1753-6405.12738.

Whole-genome landscapes of major melanoma subtypes
HAYWARD NK, Wilmott JS, Waddell N, Johansson PA, Field MA, Nones K, Patch AM, Kakavand H, Alexandrov LB, Burke H, Jakrot V, Kazakoff S, Holmes O, Leonard C, Sabarinathan R, Mularoni L, Wood S, Xu Q, Waddell N, Tembe V, Pupo GM, De Paoli-Iseppi R, Vilain RE, Shang P, Lau LMS, Dagg RA, Schramm SJ, Pritchard A, Dutton-Regester K, Newell F, Fitzgerald A, Shang CA, Grimmond SM, Pickett HA, Yang JY, Stretch JR, Behren A, Kefford RF, Hersey P, Long GV, Cebon J, Shackleton M, Spillane AJ, Saw RPM, López-Bigas N, Pearson JV, Thompson JF, Scolyer RA, Mann GJ. (2017) Whole-genome landscapes of major melanoma subtypes. Nature. 2017 May 11;545(7653):175-180.

Automated diagnosis of melanoma
Janda, Monika and Soyer, H Peter (2017) Automated diagnosis of melanoma. The Medical journal of Australia207 8: 361-362.

HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts
Jazayeri SD, Kuo PT, Leggatt GR, Frazer IH (2017) HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts. Front Immunol 2017;8:524.

Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma
Keller, Hilary R., Zhang, Xin, Li, Li, Schaider, Helmut and Wells, James W. (2017) Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma. Oncotarget, 2017 doi:10.18632/oncotarget.18523

Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging
Law MH, Medland SE, Zhu G, Yazar S, Viñuela A, Wallace L, Shekar SN, Duffy DL, Bataille V, Glass D, Spector TD, Wood D; MuTHER Consortium, Gordon SD, Barbour JM, Henders AK, Hewitt AW, Montgomery GW, Sturm RA, Mackey DA, Green AC, Martin NG, MacGregor S. (2017) Genome-Wide Association Reveals Pigmentation Genes Play a Role in Skin Aging. J Invest Dermatol. 2017 May 11. pii: S0022-202X(17)31492-6. doi: 10.1016/j.jid.2017.04.026. [Epub ahead of print]

Classifying dermoscopic patterns of naevi in a case-control study of melanoma
McWhirter, Seamus R, Duffy, David L, Lee, Katie J, Wimberley, Glen, McClenahan, Philip, Ling, Natalie, Ardigo, Marco, Schaider, Helmut, Soyer, H Peter and Sturm, Richard A (2017) Classifying dermoscopic patterns of naevi in a case-control study of melanoma. PloS one12 10: e0186647-e0186647. doi:10.1371/journal.pone.0186647

Hormonal and reproductive factors and incidence of basal cell carcinoma and squamous cell carcinoma in a large, prospective cohort
Olsen CM, Pandeya N, Thompson BS, Dusingize JC, Subramaniam P, Nagle CM, Green AC, Neale RE, Webb PM, Whiteman DC for the QSkin Study. (2017) Hormonal and reproductive factors and incidence of basal cell carcinoma and squamous cell carcinoma in a large, prospective cohort. J Am Acad Dermatol. 2017 Sep 22. pii: S0190-9622(17)32438-6. doi: 10.1016/j.jaad.2017.09.033.

Prevention of DNA damage in human skin by topical sunscreens
Olsen CM, Wilson LF, Green AC, Biswas N, Loyalka J, Whiteman DC. Prevention of DNA damage in human skin by topical sunscreens. Photodermatol Photoimmunol Photomed. 2017 May;33(3):135-142. doi: 10.1111/phpp.12298.

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin
Overgaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole L., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 2017 doi:10.1189/jlb.1AB0217-065R

Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing
Pupo GM, Boyd SC, Fung C, Carlino MS, Menzies AM, Pedersen B, Johansson P, HAYWARD NK, Kefford RF, Scolyer RA, Long GV, Rizos H. Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing. Biomark Res. 2017 May 11;5:17.

Natural killer cell heparanase controls tumor invasion and immune surveillance
Putz, E. M., Mayfosh, A., Kos, K., Barkauskas, D. S., Nakamura, K., Town, L., Goodall, K. J., Yee, D. Y., Poon, I. K. H., Baschuk, N., Souza-Fonseca-Guimaraes, F., Hulett, M., and Smyth, M. J.: Natural killer cell heparanase controls tumor invasion and immune surveillance. J. Clin. Invest. 127:2777-2788, 2017 [2].

MITF and BRN2 contribute to metastatic growth after dissemination of melanoma
Simmons, J.L., Pierce, C.J., Al-Ejeh, F. and Boyle, G.M. (2017) MITF and BRN2 contribute to metastatic growth after dissemination of melanoma. Sci. Reports. 7, 10909. doi: 10.1038/s41598-017-11366-y.

Whither melanoma in Australia?
Smithers, B Mark, Dunn, Jeff and Soyer, H Peter (2017) Whither melanoma in Australia?. The Medical journal of Australia207 8: 330-331. doi:10.5694/mja17.00740

The BRAF and NRAS mutation prevalence in dermoscopic subtypes of acquired naevi reveals constitutive MAPK pathway activation
Tan, J. M., Tom, L. N., Jagirdar, K., Lambie, D., Schaider, H., Sturm, R. A., Soyer, H. P. and Stark, M. S. (2017) The BRAF and NRAS mutation prevalence in dermoscopic subtypes of acquired naevi reveals constitutive MAPK pathway activation. British Journal of Dermatology, . doi:10.1111/bjd.15809

Use of support services in a sample of patients with high-risk primary melanomas in urban, regional and rural Queensland
von Schuckmann LA, Smithers BM, K Khosrotehrani K, Beesley VL, van der Pols JC, Hughes MB,  Green AC. (2017) Use of support services by high-risk primary melanoma patients in urban, regional and rural Queensland. ANZ J Pub Health 2017;41: 315-319.

Prognostic importance of a second invasive primary melanoma according to tumour stage
Youlden DR, Baade PD Aitken JF, Green AC, Khosrotehrani K. (2017) Prognostic importance of a second invasive primary melanoma according to tumour stage. Br J Dermatol [Epub ahead of print]

Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Young, A., Ngiow, S-F., Madore, J., Reinhardt, J., Landsberg, J., Chitsazan, A., Rautela, J., Bald, T.,Barkauskas, D. S., Ahern, E., Huntington, N. D., Schadendorf, D., Long, G. V., Boyle, G. M., Holzel, M., Scolyer, R. A., and Smyth, M. J. (2017) Targeting adenosine in BRAF-mutatnt melanoma reduces tumor growth and metastasis. Cancer Research 77: 4684-4696, 2017 [3].